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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article

Synthesis and Activity of Epothilone D

Author(s): Hao Cheng and Gangliang Huang*

Volume 19 , Issue 15 , 2018

Page: [1866 - 1870] Pages: 5

DOI: 10.2174/1389450119666180803122118

Price: $65

Abstract

Epothilones are a class of macrolide compounds. Their activities of tubulin polymerization and microtubule depolymerization inhibition like paclitaxel make them a new generation of antimitotic drugs. The mechanism of action is similar to that of paclitaxel, which can bind to tubulin and cause cancer cells to fail to undergo mitosis, thereby causing apoptosis in cancer cells. Epothilone is superior to paclitaxel in anti-tumor spectrum, anti-tumor activity, safety, water solubility and synthetic methods. It is expected to develop into a more effective anti-tumor drug than paclitaxel. Herein, the synthesis methods and activity of epothilone D were summarized and analyzed.

Keywords: Epothilone D, synthesis, activity, microtubule, depolymerization, paclitaxel.

Graphical Abstract

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