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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Review Article

Vasculitis: Decade in Review

Author(s): Selcan Demir, Hafize Emine Sönmez and Seza Özen*

Volume 15, Issue 1, 2019

Page: [14 - 22] Pages: 9

DOI: 10.2174/1573397114666180726093731

Price: $65


Background: In the last decade, we have come to better understand and manage the vasculitides. The classification of vasculitides has been revised. Genome- wide association studies and linkage analyses have been undertaken in hope of better understanding the pathogenesis of vasculitides. Comprehensive genetic studies have highlighted new pathways that may guide us in more targeted therapies. Description of the monogenic forms of vasculitis, such as deficiency of adenosine deaminase type 2 (DADA2), Haploinsufficiency of A20 (HA20), have introduced a new perspective to vasculopathies, and introduced alternative treatments for these diseases.

Conclusion: In this review, the important discoveries in pathogenesis and consensus treatment recommendations from the past decade will be summarized.

Keywords: Systemic vasculitis, treatment, pathogenesis, DADA2, genetic studies, pathways.

Graphical Abstract
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