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Cardiovascular & Hematological Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Review Article

Thromboxane A Synthase: A New Target for the Treatment of Cardiovascular Diseases

Author(s): Dinara F. Mesitskaya, Abram L. Syrkin, Marina G. Aksenova, Yong Zhang, Andrey A. Zamyatnin Jr.* and Philipp Y. Kopylov*

Volume 16 , Issue 2 , 2018

Page: [81 - 87] Pages: 7

DOI: 10.2174/1871525716666180724115132

Price: $65

Abstract

Atherothrombosis-related diseases are one of the world’s leading causes of mortality, and thus the search for new therapeutic approaches in this area remains a very urgent task. Modern pharmacogenomic technologies make it possible to obtain valuable data on disease pathogenesis and optimal therapeutic approaches. One promising research direction is the study of the thromboxane A2 - thromboxane A synthase - thromboxane A2 receptor axis. This review summarizes the recent evidence and suggests that systematic works in this area are creating new and promising opportunities in the treatment of patients with cardiovascular diseases.

Keywords: Inhibitors of thromboxane A2-synthase, pharmacogenetics, thromboxane A synthase, thromboxane, cardiovascular diseases, prostaglandins.

Graphical Abstract

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