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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Research Article

Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation

Author(s): L. Ulivi, M. Maccarrone, N. Giannini, E. Ferrari, M.C. Caselli, V. Montano, L. Chico, A. Casani, E. Navari, N. Cerchiai, G. Siciliano, U. Bonuccelli and M. Mancuso*

Volume 18, Issue 3, 2018

Page: [160 - 165] Pages: 6

DOI: 10.2174/1566524018666180720165055

open access plus


Background: Leukoaraiosis (LA) is a common radiological finding in elderly, frequently associated with several clinical disorders, including unexplained dizziness. The pathogenesis of LA is multifactorial, with a dysfunction of cerebral microcirculation resulting in chronic hypoperfusion and tissue loss, with oxidative stress involved in this cascade.

Objective: The aim of this study was to analyse some oxidative stress biomarkers in a cohort of LA patients.

Method: Fifty-five consecutive patients (33 males, median age 75 years) with LA were recruited. In a subgroup of 33 patients with LA and unexplained dizziness, we have then performed an open study to evaluate if 60-day supplementation with a polyphenol compound may modify these biomarkers and influence quality of life, analysed with the Dizziness Handicap Inventory (DHI) scale.

Results: At baseline, blood oxidative stress parameters values were outside normal ranges and compared to matched healthy controls. After the two months supplementation, we observed a significant decrement of advanced oxidation protein products values and a significant improvement of DHI.

Conclusion: Oxidative stress biomarkers may be useful to detect redox imbalance in LA and to provide non-invasive tools to monitor disease status and response to therapy.

Keywords: Leukoaraiosis, cerebral small vessel disease, dizziness, oxidative stress, polyphenols, DHI.

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