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Current Enzyme Inhibition

Editor-in-Chief

ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Research Article

Celecoxib Modulates the Renin-Angiotensin System in the Adipose Tissue of Obese Mice

Author(s): Jamille Fernandes Lula, Toni Ramos Alves de Souza, Keila Lopes Mendes, Alanna Fernandes Paraíso, Deborah de Farias Lelis, João Marcus Oliveira Andrade, Lucyana Conceição de Farias, Igor Viana Brandi, Alfredo Maurício Batista de Paula, Aline Hilzenderguer, André Luiz Sena Guimarães and Sérgio Henrique Sousa Santos*

Volume 14 , Issue 3 , 2018

Page: [203 - 209] Pages: 7

DOI: 10.2174/1573408014666180705145324

Price: $65

Sekisui-XenoTech-CEI
Abstract

Background: The renin-angiotensin system (RAS) is a critical contributing factor to obesity and related diseases. Several studies have shown the relationship of obesity with cyclooxygenase-2.

Objectives: Based on these facts, we aimed to investigate the celecoxib oral administration (a selective anti-inflammatory inhibitor of cyclooxygenase-2 (ICOX-2)) effects, in mice fed a high-fat diet by assessing the renin-angiotensin system and inflammatory markers expression.

Methods: FVB/N male mice were divided into 3 groups and fed with experimental diets, standard, high-fat diet and high-fat diet plus ICOX-2 at a dose of 100mg/kg/body weight. Body weight, food intake, blood parameters and RAS/inflammatory markers expression were assessed.

Results: The main findings showed that diet-induced obese mice treated with COX-2 inhibitor showed significantly improved glucose and insulin homeostasis, presented decreased body weight gain and the biochemical analyses revealed reduced triglyceride levels and higher serum HDL-c levels as compared to HFD and ST. These results were accompanied by a downregulation of AGT, ACE, TNF-α and IL-6 expression in the group receiving treatment.

Conclusion: Taken together, these results indicate that ICOX-2 may exhibit therapeutic potential for obesity via the renin-angiotensin system and inflammation.

Keywords: Cyclooxygenase-2, metabolic disorder, nonsteroidal anti-inflammatory drug, obesity, renin-angiotensin system, modulates.

Graphical Abstract

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