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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Research Article

Long-term Treatment with Olanzapine Increases the Number of Sox2 and Doublecortin Expressing Cells in the Adult Subventricular Zone

Author(s): Barbara Lasut, Artur Palasz*, Lukasz Filipczyk, Oscar Arias-Carrion, Ewa Rojczyk, Mariia Savchyna, Katarzyna Bogus, John J. Worthington, Marek Krzystanek and Ryszard Wiaderkiewicz

Volume 17, Issue 6, 2018

Page: [458 - 463] Pages: 6

DOI: 10.2174/1871527317666180627113544

Price: $65

Abstract

Background & Objective: Continuously active neurogenic regions in the adult brain are located in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone of the hippocampal dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics may also affect the origin of neuronal cells.

Method: The purpose of this study was to determine the effects of chronic olanzapine treatment on adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical and fluorescent detection of sex determining region Y-box 2 and doublecortin expressing cells.

Results & Conclusion: The results indicate that olanzapine has proneurogenic effects on the adult rat SVZ, as the mean number of sex determining region Y-box 2 and doublecortin-positive cells increased significantly, while there was a similar tendency in the subgranular zone. Collectively, these results suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the SVZ which supports adult neurogenesis.

Keywords: Adult neurogenesis, olanzapine, doublecortin, sex determining region Y-box 2, neuroleptics, mammalian brain.

Graphical Abstract

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