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Current Immunology Reviews (Discontinued)


ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Review Article

Mucosal Vaccine Approaches for Prevention of HIV and SIV Transmission

Author(s): Pamela A. Kozlowski and Anna Aldovini*

Volume 15, Issue 1, 2019

Page: [102 - 122] Pages: 21

DOI: 10.2174/1573395514666180605092054


Optimal protective immunity to HIV will likely require that plasma cells, memory B cells and memory T cells be stationed in mucosal tissues at portals of viral entry. Mucosal vaccine administration is more effective than parenteral vaccine delivery for this purpose. The challenge has been to achieve efficient vaccine uptake at mucosal surfaces, and to identify safe and effective adjuvants, especially for mucosally administered HIV envelope protein immunogens. Here, we discuss strategies used to deliver potential HIV vaccine candidates in the intestine, respiratory tract, and male and female genital tract of humans and nonhuman primates. We also review mucosal adjuvants, including Toll-like receptor agonists, which may adjuvant both mucosal humoral and cellular immune responses to HIV protein immunogens.

Keywords: HIV, SIV, nonhuman primates, mucosal adjuvants, rectal, vaginal, oral, nasal immunization TLR agonists, vaccine vectors, delivery vehicles.

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