Abstract
Oxidative damage is shown to affect every class of biological macromolecule in Alzheimer disease. Disruptions in iron and copper homeostasis are understood as being key players in neurodegenerative disease pathogenesis. Metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases is reviewed here with its relations to oxidative stress. While there is substantial documented evidence for alterations in transition metal metabolism, redox-activity and localization, it is also important to note that alterations in specific copper- and iron-containing metalloenzymes also contribute to the neurodegenerative process. Understanding these changes offers the opportunity to identify pathways where modification of the disease process can offer effective clinical intervention, from gene therapy to pharmaceuticals with antioxidant and chelating properties.
Keywords: neurodegenerative disease, antioxidant, chelating properties, pathogenesis of alzheimer disease, copper homeostasis, iron mediated oxidative damage
Current Medicinal Chemistry
Title: Therapeutic Potential in Alzheimer Disease
Volume: 9 Issue: 17
Author(s): A. D. Cash, G. Perry and M. A. Smith
Affiliation:
Keywords: neurodegenerative disease, antioxidant, chelating properties, pathogenesis of alzheimer disease, copper homeostasis, iron mediated oxidative damage
Abstract: Oxidative damage is shown to affect every class of biological macromolecule in Alzheimer disease. Disruptions in iron and copper homeostasis are understood as being key players in neurodegenerative disease pathogenesis. Metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases is reviewed here with its relations to oxidative stress. While there is substantial documented evidence for alterations in transition metal metabolism, redox-activity and localization, it is also important to note that alterations in specific copper- and iron-containing metalloenzymes also contribute to the neurodegenerative process. Understanding these changes offers the opportunity to identify pathways where modification of the disease process can offer effective clinical intervention, from gene therapy to pharmaceuticals with antioxidant and chelating properties.
Export Options
About this article
Cite this article as:
Cash D. A., Perry G. and Smith A. M., Therapeutic Potential in Alzheimer Disease, Current Medicinal Chemistry 2002; 9(17) . https://dx.doi.org/10.2174/0929867023369411
DOI https://dx.doi.org/10.2174/0929867023369411 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |

- Author Guidelines
- Editorial Policies
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Allegations from Whistleblowers
- Publishing Ethics and Rectitude
- Increase Visibility Of Your Article
- Archiving Policies
- Reviewer Guidelines
- Guest Editor Guidelines
- Board Recruitment Workflow
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Kinins and Cardiovascular Diseases
Current Pharmaceutical Design Bupropion-SR for Smoking Reduction and Cessation in Alcohol-Dependent Outpatients: A Naturalistic, Open-Label Study
Current Clinical Pharmacology Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine
Recent Patents on Nanomedicine Living Life to the Fullest: Early Integration of Palliative Care into the Lives of Children with Chronic Complex Conditions
Current Pediatric Reviews Genetic Variation Underlying Psychosis-inducing Effects of Cannabis: Critical Review and Future Directions
Current Pharmaceutical Design Chemo-botanical and Neurological Accounts of Some Ayurvedic Plants Useful in Mental Health
The Natural Products Journal Host Neuro- Immuno-Endocrine Responses In Periodontal Disease
Current Pharmaceutical Design Functional Peptides and Small Molecules in Medicinal Chemistry-Part II
Current Topics in Medicinal Chemistry FDG-PET for Prediction of AD Dementia in Mild Cognitive Impairment. A Review of the State of the Art with Particular Emphasis on the Comparison with Other Neuroimaging Modalities (MRI and Perfusion SPECT)
Current Alzheimer Research Connecting Parkinsons Disease and Drug Addiction: Common Players Reveal Unexpected Disease Connections and Novel Therapeutic Approaches
Current Pharmaceutical Design Pathological Role for Exocytotic Glutamate Release from Astrocytes in Hepatic Encephalopathy
Current Neuropharmacology Green Solvent: Green Shadow on Chemical Synthesis
Current Organic Synthesis Safety Considerations of the Use of Second Generation Antipsychotics in the Treatment of Major Depression: Extrapyramidal and Metabolic Side Effects
Current Drug Safety Hypothetical Link Between Infertility and Genetically Modified Food
Recent Patents on Food, Nutrition & Agriculture Role of the Central Cholinergic System in the Therapeutics of Schizophrenia
Current Neuropharmacology Classic β-Amyloid Deposits Cluster Around Large Diameter Blood Vessels Rather than Capillaries in Sporadic Alzheimers Disease
Current Neurovascular Research Species Scaling and Extrapolation
Current Drug Metabolism Diagnostic Tools, Biomarkers, and Treatments in Diabetic polyneuropathy and Cardiovascular Autonomic Neuropathy
Current Diabetes Reviews Psychoneuroimmunology - Psyche and Autoimmunity
Current Pharmaceutical Design Atypical Neuroleptic Malignant Syndrome or Serotonin Toxicity Associated with Atypical Antipsychotics?
Current Drug Safety