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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Developing Soluble Polymers for High-Throughput Synthetic Chemistry

Author(s): Carsten Spanka, Paul Wentworth Jr and Kim D. Janda

Volume 5, Issue 3, 2002

Page: [233 - 240] Pages: 8

DOI: 10.2174/1386207024607239

Price: $65

Abstract

Soluble polymers have emerged as viable alternatives to resin supports across the broad spectrum of high-throughput organic chemistry. As the application of these supports become more widespread, issues such as broad-spectrum solubility and loading are becoming limiting factors and therefore new polymers are required to overcome such limitations. This article details the approach made within our group to new soluble polymer supports and specifically focuses on parallel libraries of block copolymers, de novo poly(styrene-cochloromethylstyrene), PEG-‘stealth’ stars, and substituted poly(norbornylene)s.

Keywords: soluble polymer support, block copolymer, peg-stealth star, poly(norbornylene)


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