Abstract
Background: Candidiasis is one of the most common opportunistic fungal infections caused by genus Candida. The genus is composed of around 200 species. The most virulent among all are, Candida albicans followed by various nonalbicans species. Despite various treatments available, the incidence of severe systemic fungal infections is increasing, and with it the related morbidity and mortality, in relation to the misuse of antimicrobials and the emergence of drug-resistant fungal species. Therefore, various novel therapeutic approaches need to be developed and explored to overcome these limitations and effective management of candidiasis.
Objective: In this review, we focused on natural herbal remedies and significance of novel formulation approaches for the treatment of candidiasis.
Conclusion: The reported studies suggested the promising role of phytomedicines and novel polymeric drug delivery systems in therapeutic management of candidiasis. Phytomedicines are effective substitutes of synthetic drugs as they are inexpensive with lesser number of side effects. Various novel particulate approaches can be successfully used to reduce fungal burden at the target site.
Keywords: Candidiasis, phytomedicines, antifungal agents, novel formulations, phytopharmaceuticals, Candida albicans.
Current Pharmaceutical Design
Title:Therapeutic Potential of Phytomedicines and Novel Polymeric Strategies for Significant Management of Candidiasis
Volume: 24 Issue: 16
Author(s): Surbhi Rohilla*, D.C. Bhatt and Aditi Gupta
Affiliation:
- Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana-125001,India
Keywords: Candidiasis, phytomedicines, antifungal agents, novel formulations, phytopharmaceuticals, Candida albicans.
Abstract: Background: Candidiasis is one of the most common opportunistic fungal infections caused by genus Candida. The genus is composed of around 200 species. The most virulent among all are, Candida albicans followed by various nonalbicans species. Despite various treatments available, the incidence of severe systemic fungal infections is increasing, and with it the related morbidity and mortality, in relation to the misuse of antimicrobials and the emergence of drug-resistant fungal species. Therefore, various novel therapeutic approaches need to be developed and explored to overcome these limitations and effective management of candidiasis.
Objective: In this review, we focused on natural herbal remedies and significance of novel formulation approaches for the treatment of candidiasis.
Conclusion: The reported studies suggested the promising role of phytomedicines and novel polymeric drug delivery systems in therapeutic management of candidiasis. Phytomedicines are effective substitutes of synthetic drugs as they are inexpensive with lesser number of side effects. Various novel particulate approaches can be successfully used to reduce fungal burden at the target site.
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Cite this article as:
Rohilla Surbhi *, Bhatt D.C. and Gupta Aditi , Therapeutic Potential of Phytomedicines and Novel Polymeric Strategies for Significant Management of Candidiasis, Current Pharmaceutical Design 2018; 24 (16) . https://dx.doi.org/10.2174/1381612824666180524102933
DOI https://dx.doi.org/10.2174/1381612824666180524102933 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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