Abstract
Metabolic deregulations have emerged as a cancer characteristic, opening a broad avenue for strategies and tools to target cancer through sugar uptake and metabolism. High expression levels of sugar transporters in cancer cells offered glycoconjugation as an approach to achieve enhanced cellular accumulation of drugs and imaging agents, with the sugar moiety anchoring the bioactive cargo to cancer cells. On the other hand, high demand for sugar nutrients in cancers provided a new avenue to target cancer cells with metabolic or sugar uptake inhibitors to induce cancer cells starvation or death. This overview summarizes recent advances in targeting cancer cells through sugar transport for cancer detection and therapy.
Keywords: Carbohydrate Uptake, GLUTs, Glycoconjugates, Nanoparticles, Imaging Agents, Uptake Inhibitors, Drug Delivery, Cancer Imaging, Sugar-Disease Connection.
Current Topics in Medicinal Chemistry
Title:Targeting Sugar Uptake and Metabolism for Cancer Identification and Therapy: An Overview
Volume: 18 Issue: 6
Author(s): Marina Tanasova*, Vagarshak V. Begoyan and Lukasz J. Weselinski
Affiliation:
- Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931,United States
Keywords: Carbohydrate Uptake, GLUTs, Glycoconjugates, Nanoparticles, Imaging Agents, Uptake Inhibitors, Drug Delivery, Cancer Imaging, Sugar-Disease Connection.
Abstract: Metabolic deregulations have emerged as a cancer characteristic, opening a broad avenue for strategies and tools to target cancer through sugar uptake and metabolism. High expression levels of sugar transporters in cancer cells offered glycoconjugation as an approach to achieve enhanced cellular accumulation of drugs and imaging agents, with the sugar moiety anchoring the bioactive cargo to cancer cells. On the other hand, high demand for sugar nutrients in cancers provided a new avenue to target cancer cells with metabolic or sugar uptake inhibitors to induce cancer cells starvation or death. This overview summarizes recent advances in targeting cancer cells through sugar transport for cancer detection and therapy.
Export Options
About this article
Cite this article as:
Tanasova Marina *, Begoyan V. Vagarshak and Weselinski J. Lukasz , Targeting Sugar Uptake and Metabolism for Cancer Identification and Therapy: An Overview, Current Topics in Medicinal Chemistry 2018; 18 (6) . https://dx.doi.org/10.2174/1568026618666180523110837
DOI https://dx.doi.org/10.2174/1568026618666180523110837 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement
Current Medicinal Chemistry Dietary Quercetin Alleviated DSS-induced Colitis in Mice Through Several Possible Pathways by Transcriptome Analysis
Current Pharmaceutical Biotechnology Polymorphism in Endothelin-1 Gene: An Overview
Current Clinical Pharmacology Possible Consequences of Blocking Transient Receptor Potential Vanilloid 1
Current Pharmaceutical Biotechnology Synthesis of Some Benzothiazole Based Piperazine-Dithiocarbamate Derivatives and Evaluation of Their Anticancer Activities
Letters in Drug Design & Discovery Machine Learning for Mass Spectrometry Data Analysis in Proteomics
Current Proteomics Design, Synthesis and Evaluation of Hybrid 2-Heteroaryl Benzimidazole- Chalcone Derivatives as Anticancer Agents
Letters in Organic Chemistry A Neural Network-Based QSAR Approach for Exploration of Diverse Multi-Tyrosine Kinase Inhibitors and its Comparison with a Fragment- Based Approach
Current Computer-Aided Drug Design Catechol-O-Methyltransferase (COMT)-Mediated Methylation Metabolism of Endogenous Bioactive Catechols and Modulation by Endobiotics and Xenobiotics: Importance in Pathophysiology and Pathogenesis
Current Drug Metabolism Fibrinolytic Protease from Marine Streptomyces rubiginosus VITPSS1
Cardiovascular & Hematological Agents in Medicinal Chemistry Use of Nanoparticles as Therapy for Methicillin-Resistant Staphylococcus aureus Infections
Current Drug Metabolism Chemokines and Chemokine Receptors Blockers as New Drugs for the Treatment of Chronic Obstructive Pulmonary Disease
Current Medicinal Chemistry Role of Nitric Oxide in the Central Interferon-alpha-induced Inhibition of Gastric Acid Secretion in Rats
Current Pharmaceutical Design Discovery of Structurally Diverse Nonsteroidal SPRMs Based on a Screening Hit, 1,2-Dihydro-2,2,4-Trimethyl-6-Phenylquinolinone
Current Topics in Medicinal Chemistry Current Management of Neonatal Neuroblastoma
Current Pediatric Reviews Autophagy : Moving Benchside Promises to Patient Bedsides
Current Cancer Drug Targets Interleukin-6 and Lung Inflammation: Evidence for a Causative Role in Inducing Respiratory System Resistance Increments
Inflammation & Allergy - Drug Targets (Discontinued) Sweet and Sour - Oxidative and Carbonyl Stress in Neurological Disorders
CNS & Neurological Disorders - Drug Targets DNAzyme Delivery Approaches in Biological Settings
Current Medicinal Chemistry Targeting Angiogenesis for Treatment of NSCLC Brain Metastases
Current Cancer Drug Targets