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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Review Article

Genetics and Epigenetics Mechanism in the Pathogenesis of Behçet’s Disease

Author(s): Jibran Sualeh Muhammad*, Muhammad Ishaq and Khalid Ahmed

Volume 15 , Issue 1 , 2019

Page: [7 - 13] Pages: 7

DOI: 10.2174/1573397114666180521090335

Price: $65


Background: Behçet’s Disease (BD) is characterized by numerous systemic manifestations and is known for its ability to affect both, arteries and the veins. However, the etiology of BD is only partially understood, and previous studies have demonstrated a role for genetic and epigenetic factors that contribute to disease pathophysiology. Several studies have implicated T cells and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock proteins and streptococcal antigen. Furthermore, during disease exacerbations adenosine deaminase has an important role in activating lymphocyte proliferation, maturation, and differentiation in BD. This article presents a review of the published literature mainly from the last 20 years. The topics of main concern were the role of genetic and epigenetic factors as contributing factors in disease pathophysiology.

Result and Conclusion: The authors used MeSH terms “Behçet’s disease” with “pathophysiology,” “pathogenesis,” “genetic” or “epigenetic” to search the PubMed database. All the relevant studies identified were included and are described according to the aforementioned subheadings.

Keywords: Behçet's disease, genetics, epigenetics, arteries, veins, pathogenesis.

Graphical Abstract
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