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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Research Article

Synthesis and Cytotoxicity Studies on Novel Piperazinylacetamides

Author(s): Eman Bobtaina, Enise Ece Gurdal*, Irem Durmaz, Rengul Cetin Atalay and Mine Yarim

Volume 16, Issue 1, 2019

Page: [45 - 51] Pages: 7

DOI: 10.2174/1570180815666180501124009

Price: $65

Abstract

Background: In this study, nine novel compounds, bearing N-[2-(4-substituted piperazine-1-yl)acetyl]-N’-[bis-(4-fluorophenyl)methyl]piperazine structures were synthesized.

Methods: Their cytotoxic properties were evaluated in vitro by NCI-60 Sulforhodamine B (SRB) assay against human cancer cell lines: Huh7 (hepatocellular), MCF7 (breast) and HCT116 (colorectal).

Results and Conclusion: According to the activity data, most of the compounds are more cytotoxic than 5-fluorouracil against Huh7 and HCT116 cancer cell lines.

Keywords: Acetamide, anticancer, benzhydrylpiperazine, cytotoxicity, piperazine, sulforhodamine B.

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