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Current Radiopharmaceuticals


ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Review Article

Dosimetry and Radiobiology of Alpha-Particle Emitting Radionuclides

Author(s): George Sgouros*, Robert Hobbs and Anders Josefsson

Volume 11, Issue 3, 2018

Page: [209 - 214] Pages: 6

DOI: 10.2174/1874471011666180426130058

Price: $65


Background: Radiopharmaceutical therapy is a cancer treatment modality by which radiation is delivered directly to targeted tumor cells or to their microenvironment. This makes it possible to deliver highly potent alpha-particle radiation. The short-range and highly potent nature of alpha-particles require a dosimetry methodology that considers microscale distributions of the alpha-emitting agent. The high energy deposition density along an alpha-particle track causes a spectrum of DNA lesions. The majority of these are irreparable DNA double-stranded breaks. Accordingly the biologic effects of alpha- particles are largely impervious to the adaptive and resistance mechanism that renders other therapeutics ineffectual.

Objectives: In this review, the radiobiology and dosimetry of alpha-particle emitting radionuclides as related to their use in radiopharmaceutical therapy, are presented.

Conclusion: Alpha-particle emitter radiopharmaceutical therapy is distinguished from other treatment modalities. Its safe clinical use requires an understanding of its unique dosimetry and radiobiology.

Keywords: Radiopharmaceutical therapy, alpha-particles, treatment planning, DNA damage, relative biological efficacy.

Graphical Abstract

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