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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Neurotransmission and Neurotoxicity by Nitric Oxide, Catecholamines, and Glutamate: Unifying Themes of Reactive Oxygen Species and Electron Transfer

Author(s): Jason D. Jacintho and Peter Kovacic

Volume 10 , Issue 24 , 2003

Page: [2693 - 2703] Pages: 11

DOI: 10.2174/0929867033456404

Price: $65


This review treats the mechanism of nitric oxide, catecholamines, and glutamate as important neurotransmitters and as neurotoxins, based on involvement of reactive oxygen species (ROS) and electron transfer (ET). ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Cell signaling, electrochemistry, antioxidants, and apoptosis are also discussed.

Keywords: nitric oxide, catecholamines, glutamate, neurotransmission, neurotoxicity, oxidative stress, reactive oxygen species

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