Background: Epidemiological studies have shown the role of high dietary fat intake as a risk factor for Neuropsychiatric Disorders (NPDs). However, the exact mechanism of this phenomenon is unknown.
Methods: An electronic search was performed using Scopus, PubMed and Google Scholar regarding the association of high fat intake and inflammatory reactions and their roles in the etiopathogenesis of NPDs.
Results: The results indicate that high fat intake is involved in the development of severe inflammatory reactions. Inflammation is also involved in the pathophysiology of NPDs. Therefore, it is suggested that high fat intake might be involved in the development of NPDs through induction of inflammatory reactions.
Conclusion: It is suggested that reducing fat intake might decline the risk of NPDs.