Abstract
An efficient and eco-friendly process has been developed for the synthesis of α- aminophosphonates containing aminothiazole moiety via Kabachnik-Field reaction catalyzed by H6P2W18O62.14H2O as reusable catalyst, by condensation of aromatic aldehydes, 2-aminothiazole and triethylphosphite under solvent-free conditions. All the newly synthesized compounds were systematically characterized by IR, 1H NMR, 13C NMR and 31P NMR analysis. The X-ray crystallographic data of compounds 3f and 3j were provided. Simplicity, inexpensive catalyst, milder, short reaction times and easy workup and purification of the final product are the main advantages of this method.
Keywords: 2-aminothiazole, α-aminophosphonates, one-pot reaction, H6P2W18O62.14H2O catalyst, solvent-free, X-ray study.
Current Organic Chemistry
Title:H6P2W18O62.14H2O Catalyzed Synthesis, Spectral Characterization and X-ray Study of α-Aminophosphonates Containing Aminothiazole Moiety
Volume: 22 Issue: 13
Author(s): Sara Boughaba, Sofiane Bouacida, Zineb Aouf, Ouahiba Bechiri and Nour-Eddine Aouf*
Affiliation:
- Department of Chemistry, Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Faculty of Sciences, Badji Mokhtar- Annaba University, Box 12, 23000 Annaba,Algeria
Keywords: 2-aminothiazole, α-aminophosphonates, one-pot reaction, H6P2W18O62.14H2O catalyst, solvent-free, X-ray study.
Abstract: An efficient and eco-friendly process has been developed for the synthesis of α- aminophosphonates containing aminothiazole moiety via Kabachnik-Field reaction catalyzed by H6P2W18O62.14H2O as reusable catalyst, by condensation of aromatic aldehydes, 2-aminothiazole and triethylphosphite under solvent-free conditions. All the newly synthesized compounds were systematically characterized by IR, 1H NMR, 13C NMR and 31P NMR analysis. The X-ray crystallographic data of compounds 3f and 3j were provided. Simplicity, inexpensive catalyst, milder, short reaction times and easy workup and purification of the final product are the main advantages of this method.
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Cite this article as:
Boughaba Sara , Bouacida Sofiane , Aouf Zineb , Bechiri Ouahiba and Aouf Nour-Eddine *, H6P2W18O62.14H2O Catalyzed Synthesis, Spectral Characterization and X-ray Study of α-Aminophosphonates Containing Aminothiazole Moiety, Current Organic Chemistry 2018; 22 (13) . https://dx.doi.org/10.2174/1385272822666180404145804
DOI https://dx.doi.org/10.2174/1385272822666180404145804 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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