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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Cytotoxic Pyran-based Cembranoids from Sarcophyton glaucum

Author(s): Walied M. Alarif*, Zahra A. Al-Saihati, Mohamed H. Ph, Ahmed Abdel-Lateff, Mahmoud A. Elfaky, Nahed O. Bawakid, Najla A. Alburae and Hajer S. Alorfi

Volume 15 , Issue 11 , 2018

Page: [967 - 971] Pages: 5

DOI: 10.2174/1570178615666180326154819

Price: $65

Abstract

Four new pyran-based cembranoidal diterpenes (1-4) were isolated from the Red Sea softbodied coral Sarcophyton glaucum. Sarcoglauphine A (1) and B (2) are conformers with respect to the dihedral angle between H-7 and the pair of H-6a, 6b, while sarcotrocheliol-B acetate (3) and sarcotrochelione (4) are bicyclic cembranoids. The chemical structures of the isolated compounds were elucidated using spectroscopic methods. The cytotoxicity of the isolated compounds were evaluated against HepG2, MCF-7, and HCT116 cell lines by employing Sulforhodamine B (SRB) method. Compounds 1 and 2 showed significant activities toward HCT116.

Keywords: Soft coral, red sea, isomers, oxirane, diterpenoids, cemberane.

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