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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Research Article

Synthesis of (2-iminomethyl)pyridine Moiety Supported on Hydroxyapatiteencapsulated-γ-Fe2O3 as an Inorganic-organic Hybrid Magnetic Nanocatalyst for the Synthesis of Thiazole Derivatives under Ultrasonic Irradiation

Author(s): Mohammad Ahmadiazar and Manouchehr Mamaghani*

Volume 22, Issue 13, 2018

Page: [1326 - 1334] Pages: 9

DOI: 10.2174/1385272822666180322121544

Price: $65

Abstract

A novel pyridine base modified core-shell (γ-Fe2O3@Hap (Hap: Hydroxyapatite)) inorganic-organic hybrid magnetic nanocatalyst has been introduced. The catalyst was fully characterized by spectroscopic analyses (FT-IR, FESEM, EDX, XRD) and its efficiency evaluated as a basic catalyst in one-pot multicomponent reaction of aryl aldehydes, rhodanine and piperidine under ultrasonic irradiation to obtain thiazole derivatives. This green, fast and straightforward protocol produced the products in short reaction times (14-40 min) and high to excellent yields (75-95%).

Keywords: γ-Fe2O3@HAp, thiazole, rhodanine, thiazolone, ultrasonic irradiation, multicomponent reaction.

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