Abstract
Insulin Resistance (IR) is a physiological condition in which pancreatic cells fail to respond to normal actions of insulin hormone. It is a milestone for the development of diabetes and its complications. The current approach for the treatment of the diabetes and insulin resistance includes pharmacotherapeutics. However, this therapy includes the development of drug tolerance, potential toxicity and inadequate relief warranting the investigation of newer approaches for treatment. A potentially safe and effective therapeutic treatment for insulin resistance (IR) in diabetes is required. The current research is focused on herbal or phytochemical drugs. The potential herbal targets with insulin mimetic, secretagogues and promising activity are under the scope of this review. In this review, we have discussed the herbal targets and non-pharmacological approaches for the treatment of IR in diabetes. This review aims to compile the relevant information regarding various phases of drug development for the management of the insulin resistance and highlight the future prospective for its treatment by natural and semi-synthetic drugs.
Keywords: Diabetes, insulin resistance, semi-synthetic drugs, treatment, pharmacotherapeutics, natural drugs.
Current Psychopharmacology
Title:Insulin Resistance in Diabetes: Present and Future Prospective of Treatment
Volume: 7
Author(s): Anil Kumar*, Ruchika Mittal and Ashmeen Kaur
Affiliation:
- Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh,India
Keywords: Diabetes, insulin resistance, semi-synthetic drugs, treatment, pharmacotherapeutics, natural drugs.
Abstract: Insulin Resistance (IR) is a physiological condition in which pancreatic cells fail to respond to normal actions of insulin hormone. It is a milestone for the development of diabetes and its complications. The current approach for the treatment of the diabetes and insulin resistance includes pharmacotherapeutics. However, this therapy includes the development of drug tolerance, potential toxicity and inadequate relief warranting the investigation of newer approaches for treatment. A potentially safe and effective therapeutic treatment for insulin resistance (IR) in diabetes is required. The current research is focused on herbal or phytochemical drugs. The potential herbal targets with insulin mimetic, secretagogues and promising activity are under the scope of this review. In this review, we have discussed the herbal targets and non-pharmacological approaches for the treatment of IR in diabetes. This review aims to compile the relevant information regarding various phases of drug development for the management of the insulin resistance and highlight the future prospective for its treatment by natural and semi-synthetic drugs.
Export Options
About this article
Cite this article as:
Kumar Anil *, Mittal Ruchika and Kaur Ashmeen , Insulin Resistance in Diabetes: Present and Future Prospective of Treatment, Current Psychopharmacology 2018; 7 (2) . https://dx.doi.org/10.2174/2211556007666180309155102
DOI https://dx.doi.org/10.2174/2211556007666180309155102 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
Call for Papers in Thematic Issues
Breakthroughs in drug design, development and delivery system for the management of neuro-psychiatric disorders
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. This proposal describes the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Lung in Sepsis: Guilty or Innocent?
Endocrine, Metabolic & Immune Disorders - Drug Targets Integrating Bioinformatics and Computational Biology: Perspectives and Possibilities for In Silico Network Reconstruction in Molecular Systems Biology
Current Bioinformatics Earthworms as a Source of Bioactive Molecules
Current Bioactive Compounds Protein Tyrosine Phosphatase 1B Inhibitors: A Novel Therapeutic Strategy for the Management of type 2 Diabetes Mellitus
Current Pharmaceutical Design Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets
Current Medicinal Chemistry Conventional and Novel Approaches in Generating and Characterization of Reactive Intermediates from Drugs/Drug Candidates
Current Drug Metabolism Regeneration of Pancreatic β-Cells in vivo as a Potential Therapeutic Approach for Diabetes Mellitus
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Human Pluripotent Stem Cells for Modelling Human Liver Diseases and Cell Therapy
Current Gene Therapy Potential Mechanisms of Failure in the Sudden Infant Death Syndrome
Current Pediatric Reviews Diagnosis and Treatment of Alzheimers Disease
Current Medicinal Chemistry - Central Nervous System Agents Colloid Update
Current Pharmaceutical Design VEGF and HIF in Renal Cell Carcinogenesis
Recent Patents on Biomarkers Tolerance in the Absence of Autoantigen
Endocrine, Metabolic & Immune Disorders - Drug Targets Malaria and Leishmaniasis: Current Status of Chemotherapy, New Leads and Targets for Drug Discovery
Anti-Infective Agents in Medicinal Chemistry Neuroleptics and Migraine
Central Nervous System Agents in Medicinal Chemistry Intravitreal Bevacizumab for Diabetic Retinopathy
Current Diabetes Reviews Nutrigenomics: Advances, Opportunities and Challenges in Understanding the Nutrient-Gene Interactions
Current Nutrition & Food Science Cell-Permeable Peptide Inhibitor of c-Jun NH2-Terminal Kinase for the Treatment of Diabetes
Current Bioactive Compounds Comparison of the Effects of Dexamethasone Administration on Postoperative Sequelae Before and After “Third Molar" Extraction Surgeries
Endocrine, Metabolic & Immune Disorders - Drug Targets SGLT2 Inhibitors in Diabetes Mellitus Treatment
Reviews on Recent Clinical Trials