Abstract
Graphene and graphene oxide topography have an effect on the fate of stem cells such as adhesion, differentiation, and proliferation. This overview clearly shows that a new design and manipulation of associated graphene oxide stem cell culture platforms are of paramount importance as a focus in stem cell to tissue engineering applications. This overview also proposes that a film of graphene oxide is an efficient platform to modulate structure and function of multipotent mesenchymal stem/stromal cells (MSCs) and in special human adipose tissue derived mesenchymal stromal/stem cells (AT-MSCs). The implication of graphene oxide on osteogenesis, neurogenesis, oligodendrogenesis, adipogenic and epithelial differentiation is also discussed. Graphene oxide toxicity on stem cells and the importance of GO application on ATMSCs differentiation and proliferation are final topics that are being discussed.
Keywords: Stem cells, graphene oxide, adipose tissue derived mesenchymal stromal/stem cells, topography, differentiation, tissue engineering.
Current Molecular Medicine
Title:Graphene Oxide as Scaffolds for Stem Cells: An Overview
Volume: 17 Issue: 9
Author(s): M. Duran, A.C.M. Luzo, J.G. de Souza, W.J. Favaro*, P. Garcia and N. Duran*
Affiliation:
- Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, Department Genetics, Evolution and Bioagents, University of Campinas, Campinas, SP,Brazil
- NanoBioss-Institute of Chemistry, University of Campinas, Campinas, SP,Brazil
Keywords: Stem cells, graphene oxide, adipose tissue derived mesenchymal stromal/stem cells, topography, differentiation, tissue engineering.
Abstract: Graphene and graphene oxide topography have an effect on the fate of stem cells such as adhesion, differentiation, and proliferation. This overview clearly shows that a new design and manipulation of associated graphene oxide stem cell culture platforms are of paramount importance as a focus in stem cell to tissue engineering applications. This overview also proposes that a film of graphene oxide is an efficient platform to modulate structure and function of multipotent mesenchymal stem/stromal cells (MSCs) and in special human adipose tissue derived mesenchymal stromal/stem cells (AT-MSCs). The implication of graphene oxide on osteogenesis, neurogenesis, oligodendrogenesis, adipogenic and epithelial differentiation is also discussed. Graphene oxide toxicity on stem cells and the importance of GO application on ATMSCs differentiation and proliferation are final topics that are being discussed.
Export Options
About this article
Cite this article as:
Duran M. , Luzo A.C.M., de Souza J.G., Favaro W.J.*, Garcia P. and Duran N. *, Graphene Oxide as Scaffolds for Stem Cells: An Overview, Current Molecular Medicine 2017; 17 (9) . https://dx.doi.org/10.2174/1566524018666180308111915
DOI https://dx.doi.org/10.2174/1566524018666180308111915 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hypopituitarism in the Elderly: Multifaceted Clinical and Biochemical Presentation
Current Aging Science Patent Selections
Recent Patents on Biomarkers Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation
Current Alzheimer Research Editorial [Hot Topic: Sepsis: Evolving Concepts and Therapeutic Strategies (Executive Editors: T.J. Standiford and M. Moss) ]
Current Pharmaceutical Design “Self-Nonself” Peptides in the Design of Vaccines
Current Pharmaceutical Design Ligand-Based Peptide Design and Combinatorial Peptide Libraries to Target G Protein-Coupled Receptors
Current Pharmaceutical Design Gender Differences in Cancer-associated Venous Thromboembolism
Current Medicinal Chemistry Targeting Soluble Epoxide Hydrolase for Inflammation and Pain - An Overview of Pharmacology and the Inhibitors
Inflammation & Allergy - Drug Targets (Discontinued) Electrochemical Detection and Sensing of Reactive Oxygen Species
Current Organic Chemistry Review of Recent Clinical Developments and Patents for the Treatment of Autoimmune and Inflammatory Diseases by Mesenchymal Stromal Cells
Recent Patents on Regenerative Medicine Liraglutide for the Treatment of Obesity: Analyzing Published Reviews
Current Pharmaceutical Design Somatostatin, Somatostatin Analogs and Somatostatin Receptor Dynamics in the Biology of Cancer Progression
Current Molecular Medicine Pharmacological Management of Hypertension in the Elderly - Certitudes and Controversies
Current Pharmaceutical Design Biological Effect of Glycosyl-Oxadiazolinethione and Glycosyl-sulfanyloxadiazole Derivatives through their in vitro Inhibition of Glycosidases from Bacteria and Normal or Diabetic Rats
Letters in Drug Design & Discovery Anti-Tumor Effects of Osthole on Different Malignant Tissues: A Review of Molecular Mechanisms
Anti-Cancer Agents in Medicinal Chemistry B7-H3 Immune Checkpoint Protein in Human Cancer
Current Medicinal Chemistry Diagnostic Value of the Early Heart-to-Mediastinum Count Ratio in Cardiac 123I-mIBG Imaging for Parkinson's Disease
Current Radiopharmaceuticals Cytokine Gene Variants as Predictors of Type 2 Diabetes Mellitus
Current Diabetes Reviews A Disposable, Highly Sensitive Biosensing System: Determination of Haptoglobin as a Significant Acute Phase Biomarker
Current Analytical Chemistry Exploring Modifications in Fetal Telomere Programming in Mothers Exposed to Multiple Risk Factors
Current Women`s Health Reviews