Synthesis of 1,1’-Ferrocene Diformates Bearing Isoxazole Moiety and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines

Title:Synthesis of 1,1’-Ferrocene Diformates Bearing Isoxazole Moiety and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines

Volume: 15 Issue: 11

Author(s): Jianping Yong*, Mingxue Yang, Canzhong Lu*Xiaoyuan Wu

Affiliation:

• Xiamen Institute of Rare-earth Materials, Chinese Academy of Sciences, Xiamen 361021,China

• Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002,China

Keywords: 1, 1`-ferrocene diformates, isoxazole moiety, synthesis, structural characterization, antitumor activity, cell lines.

Abstract: Background: Ferrocene is a potential pharmacophore for drug design and drug discovery.

Methods: Based on our previous good achievements (Med. Chem. commun., 2014,7,968-972), nineteen novel structures of 1,1’-ferrocene diformates bearing isoxazole moiety (3a-3s) were firstly synthesized in the current work and characterized by 1H NMR, 13C NMR, ESI-MS. Then, their cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method.

Results: The results showed that most compounds exhibited higher potent cytotoxicity to A549, HCT116 and MCF-7 cell lines.

Conclusion: Especially, 3b, 3h, 3k, 3l, 3m, 3n, 3o, 3p and 3s simultaneously exhibited stronger inhibitory activity towards A549, HCT116 and MCF-7 cell lines than that of the reference drug cisplatin, which can be regarded as very promising metal-based lead compounds for anticancer agents.

Cite this article as:

Yong Jianping*, Yang Mingxue , Lu Canzhong *, Wu Xiaoyuan , Synthesis of 1,1’-Ferrocene Diformates Bearing Isoxazole Moiety and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines, Letters in Drug Design & Discovery 2018; 15 (11) . https://dx.doi.org/10.2174/1570180815666180306124920