Review Article

具有氨基硫脲基元和相关杂环化合物的金属离子配合物的抗微生物和结构特性

卷 26, 期 4, 2019

页: [664 - 693] 页: 30

弟呕挨: 10.2174/0929867325666180228164656

价格: $65

摘要

由各种细菌真菌和病毒病原体获得的抗生素抗性引起严重性增加的治疗问题。在非常难以治疗的感染中,生物膜相关病例是最危险的病例之一。生物膜的复杂结构和生物膜细胞的独特生理学有助于其对环境条件,抗微生物剂和宿主免疫应答机制的极高抗性。因此,生物膜形成,特别是多药耐药性病原体,是一种严重的医学问题,在慢性和复发性感染的发展中起关键作用。这些因素限制了使用传统化学疗法,并有助于开发治疗传染病的新方法。因此,早期关于几种金属离子配合物(含有氨基硫脲或缩氨基硫脲)作为配体的抗微生物活性的报道,促进了全世界寻找这类新的,更有效的化合物,以用作常用药物的替代品。通常,取决于其他杂原子的存在,这些配体可以以二 - ,三 - 或四齿形式(例如,N,S, - ,N,N,S-,N,N,N,S-)起作用。 ,N,N,S,S-或N,S,O-型),其对所得复合物施加不同的配位几何形状。在本综述的第一部分中,我们描述了基于缩氨基硫脲基序的合成方式和配体结构,而第二部分介绍了它们与选定金属离子的复合物的抗菌活性。

关键词: 氨基硫脲衍生物,缩氨基硫脲,抗菌性,抗生素抗性,金属离子络合物结构,抗菌,抗真菌,抗病毒。

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