摘要
介绍:骨组织有一种内在的修复和再生能力,通过一个持续的重建循环,吸收旧的或受损的骨头和沉积新的。然而,重要的是当骨头不能自行愈合时,NT的发病率和死亡率就会增加。有效的骨再生策略可以改善目前许多骨科疾病的临床治疗。细胞活动刺激、生长因子和适当的机械条件是临床治疗的重要组成部分。然而,生长因子倾向于随时间在人体中降解。 基因治疗提供了一个改变治疗骨缺损的本土方法,随着基因载体新的传递能力的出现。基因载体准确地将再生分子传递到病变部位。另外,E治疗提供了一个高效的治疗方案,有效浓度较低。与病毒基因载体相比,非病毒基因载体的安全性更强,无免疫原性,制造方便。 结论:本文就非病毒基因载体治疗在骨再生中的应用及进展作一综述。
关键词: 骨再生,DNA传递,基因治疗,非病毒载体,骨组织,细胞。
Current Gene Therapy
Title:Applications and Prospects of Non-viral Vectors in Bone Regeneration
Volume: 18 Issue: 1
关键词: 骨再生,DNA传递,基因治疗,非病毒载体,骨组织,细胞。
摘要: Introduction: Bone tissue has an intrinsic ability to repair and regenerate itself through a continuous remodelling cycle of resorption of old or damaged bone and deposition of new. However, significant morbidity and mortality arise when bone cannot heal itself. Effective bone regeneration strategy can improve the current clinical therapies of many orthopaedic disorders. Cell activity stimulation, growth factors, and appropriate mechanical conditions are essential components of clinical treatment. However, growth factors tend to degrade over time in the human body. Gene therapy offers an alternative method to cure bone defects, with the advent of exciting new delivery capabilities via gene vectors. Gene vectors accurately deliver regenerative molecules to the lesion site. Additionally, gene therapy provides a highly efficient treatment option with a lower effective concentration. Compared with viral gene vectors, non-viral gene vectors have proven to be more potent due to their safety, non-immunogenicity, and ease of manufacture.
Conclusion: Thus, in this paper, we review the application and progress of non-viral gene vector therapy in bone regeneration.
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Cite this article as:
Applications and Prospects of Non-viral Vectors in Bone Regeneration, Current Gene Therapy 2018; 18 (1) . https://dx.doi.org/10.2174/1566523218666180227154232
DOI https://dx.doi.org/10.2174/1566523218666180227154232 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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