Applications and Prospects of Non-viral Vectors in Bone Regeneration

Title:Applications and Prospects of Non-viral Vectors in Bone Regeneration

Volume: 18 Issue: 1

Author(s): Wei Yang, Fengzhe Wang, Longbao Feng, Shina Yan and Rui Guo*

Affiliation:

• Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632,China

Keywords: Bone regeneration, DNA delivery, Gene therapy, Non-viral vector, Bone tissue, Cell.

Abstract: Introduction: Bone tissue has an intrinsic ability to repair and regenerate itself through a continuous remodelling cycle of resorption of old or damaged bone and deposition of new. However, significant morbidity and mortality arise when bone cannot heal itself. Effective bone regeneration strategy can improve the current clinical therapies of many orthopaedic disorders. Cell activity stimulation, growth factors, and appropriate mechanical conditions are essential components of clinical treatment. However, growth factors tend to degrade over time in the human body. Gene therapy offers an alternative method to cure bone defects, with the advent of exciting new delivery capabilities via gene vectors. Gene vectors accurately deliver regenerative molecules to the lesion site. Additionally, gene therapy provides a highly efficient treatment option with a lower effective concentration. Compared with viral gene vectors, non-viral gene vectors have proven to be more potent due to their safety, non-immunogenicity, and ease of manufacture.

Conclusion: Thus, in this paper, we review the application and progress of non-viral gene vector therapy in bone regeneration.

Cite this article as:

Yang Wei , Wang Fengzhe , Feng Longbao , Yan Shina and Guo Rui *, Applications and Prospects of Non-viral Vectors in Bone Regeneration, Current Gene Therapy 2018; 18 (1) . https://dx.doi.org/10.2174/1566523218666180227154232