摘要
炎症性肠病(IBD)包括两种影响全世界约300万人的特发性慢性肠道炎症疾病:克罗恩病和溃疡性结肠炎。现在对于有轻度到中度症状的IBD患者,第一道治疗方案是由皮质类固醇、免疫抑制剂、抗生素和生物制剂组成的。不幸的是,没有一个ESE药物是有效的,长期使用可能会引起严重的副作用和并发症.近40%的IBD患者使用替代疗法来补充常规疗法和类黄酮类药物。正为此目的引起人们的关注。黄酮类化合物的生物学特性得到了广泛的研究,其抗氧化和抗炎活性已引起科学界的广泛关注。集成电路社区。黄酮类化合物是植物和水果中分布最广的多酚类化合物,是人类饮食的一部分。考虑到所有摄入的黄酮类化合物都有望发挥生物学作用。CAL在胃肠道的作用,研究这些化合物在IBD中的调节作用是至关重要的。本审查的目的是以综合和全面的方式进行总结。黄酮类化合物的形成、作用,无论在体外还是在体内,在IBD炎症网络的不同阶段都具有特征性。
关键词: 黄酮类化合物,炎症性肠病,溃疡性结肠炎,克罗恩病,体内实验模型,营养品。
Current Medicinal Chemistry
Title:Immunomodulatory Effects of Flavonoids in the Prophylaxis and Treatment of Inflammatory Bowel Diseases: A Comprehensive Review
Volume: 25 Issue: 28
关键词: 黄酮类化合物,炎症性肠病,溃疡性结肠炎,克罗恩病,体内实验模型,营养品。
摘要: Inflammatory Bowel Diseases (IBD) comprised of two disorders of idiopathic chronic intestinal inflammation that affect about three million people worldwide: Crohn’s disease and ulcerative colitis. Nowadays, the first-line of treatment for patients with mild to moderate symptoms of IBD is comprised of corticosteroids, immunosuppressants, antibiotics, and biological agents. Unfortunately, none of these drugs are curative, and their long-term use may cause severe side effects and complications. Almost 40% of IBD patients use alternative therapies to complement the conventional one, and flavonoids are gaining attention for this purpose. The biological properties of flavonoids are well documented and their antioxidant and anti-inflammatory activities have been arousing attention in the scientific community. Flavonoids are the most widely distributed polyphenols in plants and fruits, making part of the human diet. Taking into account that all ingested flavonoids are expected to exert biological actions at the gastrointestinal level, research on the modulatory effect of these compounds in IBD is of paramount importance. This review intends to summarize, in an integrated and comprehensive form, the effect of flavonoids, both in vitro and in vivo, in the different phases of the characteristic IBD inflammatory network.
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Cite this article as:
Immunomodulatory Effects of Flavonoids in the Prophylaxis and Treatment of Inflammatory Bowel Diseases: A Comprehensive Review, Current Medicinal Chemistry 2018; 25 (28) . https://dx.doi.org/10.2174/0929867325666180214121734
DOI https://dx.doi.org/10.2174/0929867325666180214121734 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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