Abstract
The development of new antimicrobial drugs is a very challenging task owing to the rapidly developing drug resistance among the existing drugs. The hybridization of active and novel compounds is a commonly used approach to combat this situation. The azo linkage (N=N) is successfully used to link two bioactive moieties to enhance the therapeutic effects. The hybrid derivatives linked by azo linkage have shown their activity by acting on target proteins in microorganisms, cell wall inhibitors, DHPS inhibitors, RNA Editing Ligase 1 inhibitors, the general protein secretory (Sec) pathway inhibitors, neuraminidase inhibitors, etc. The current review covers the general enzymes and regulatory pathways in microorganisms targeted by diazenyl compounds and recent developments pertaining to diazenyl derivatives as antimicrobial agents during the last five years. This information will prove useful to the researchers for the development of novel antimicrobial agents by slight modifications in active derivatives with improved activities.
Keywords: Antimicrobial, Neuraminidase, Diazenyl, Virulence, Hybridization, RNA.
Current Topics in Medicinal Chemistry
Title:Antimicrobial Activity of Diazenyl Derivatives: An Update
Volume: 18 Issue: 1
Author(s): Harmeet Kaur and Balasubramanian Narasimhan*
Affiliation:
- Department of Pharmaceutical Sciences, M.D University, Rohtak, Haryana 124001,India
Keywords: Antimicrobial, Neuraminidase, Diazenyl, Virulence, Hybridization, RNA.
Abstract: The development of new antimicrobial drugs is a very challenging task owing to the rapidly developing drug resistance among the existing drugs. The hybridization of active and novel compounds is a commonly used approach to combat this situation. The azo linkage (N=N) is successfully used to link two bioactive moieties to enhance the therapeutic effects. The hybrid derivatives linked by azo linkage have shown their activity by acting on target proteins in microorganisms, cell wall inhibitors, DHPS inhibitors, RNA Editing Ligase 1 inhibitors, the general protein secretory (Sec) pathway inhibitors, neuraminidase inhibitors, etc. The current review covers the general enzymes and regulatory pathways in microorganisms targeted by diazenyl compounds and recent developments pertaining to diazenyl derivatives as antimicrobial agents during the last five years. This information will prove useful to the researchers for the development of novel antimicrobial agents by slight modifications in active derivatives with improved activities.
Export Options
About this article
Cite this article as:
Kaur Harmeet and Narasimhan Balasubramanian *, Antimicrobial Activity of Diazenyl Derivatives: An Update, Current Topics in Medicinal Chemistry 2018; 18 (1) . https://dx.doi.org/10.2174/1568026618666180206093107
DOI https://dx.doi.org/10.2174/1568026618666180206093107 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Graft Versus Host Disease
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents An Overview of Nanoformulated Nutraceuticals and their Therapeutic Approaches
Current Nutrition & Food Science Plant Phenolic Compounds as Potential Lead Compounds in Functional Foods for Antiviral Drug Discovery
Current Organic Chemistry Metallopharmaceuticals in Therapy - A New Horizon for Scientific Research
Current Medicinal Chemistry Pharmaco-Therapeutic Challenges in Cancer Biology with Focus on the Immune- System Related Risk Factors
Current Pharmaceutical Design Mechanisms of Interferon Mediated Anti-Viral Resistance
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Antioxidant Potential of Solvent Partitioned Extraction from Aqueous Extract of Gracilaria Tenuistipitata
Current Organic Chemistry Gene Profile Identifies Zinc Transporters Differentially Expressed in Normal Human Organs and Human Pancreatic Cancer
Current Molecular Medicine Recent Progress and Related Patents on the Applications of Bone Marrow-Derived Stem/Progenitor Cells in Regenerative Medicine and Cancer Therapies
Recent Patents on Regenerative Medicine The Application of Cell-Penetrating-Peptides in Antibacterial Agents
Current Medicinal Chemistry Human Kallikreins: Common Structural Features, Sequence Analysis and Evolution
Current Genomics Using an Ancient Tool for Igniting and Propagating Immune Tolerance: IDO as an Inducer and Amplifier of Regulatory T Cell Functions
Current Medicinal Chemistry Fungal Biotechnology of the Red Sea Alga Sarggassum subrepandum with Potential of Anticancer and Anti-Hepatitis C Virus Protease Activities
Letters in Organic Chemistry The Yin and Yang of Inflammation
Current Molecular Medicine The Effect of Psychological Stress and Social Isolation on Neuroimmunoendocrine Communication
Current Pharmaceutical Design Trypanosomatid Enzymes as Targets for Plant-Derived Compounds: New Perspectives for Phytotherapeutic Approaches
Current Enzyme Inhibition Electrochemical DNA Detection Using Carbon Nanotubes
Current Physical Chemistry IAPs as a Target for Anticancer Therapy
Current Cancer Drug Targets Targeting Tumor-Associated Antigens to the MHC Class I Presentation Pathway
Endocrine, Metabolic & Immune Disorders - Drug Targets Neuroprotective Effects of Non-Classical Estrogen-Like Signaling Activators: from Mechanism to Potential Implications
CNS & Neurological Disorders - Drug Targets