摘要
背景:年龄较小的维生素D缺乏症患者更常报告主观认知症状,尤其是记忆力方面。这提出了维生素D可以改善老年人记忆障碍的主观体验的前景。 目的:确定较旧的社区居民是否较高的血清25-羟基维生素D(25OHD)浓度与较少的记忆投诉相关,同时考虑不同亚型的记忆投诉。 方法:本研究纳入1980名来自法国EVATEM研究的记忆投诉和无痴呆(平均数±标准差,71.1±3.4岁; 33.3%女性)的80名白人社区居民。使用标准化问卷评估记忆失误,学习新信息的问题,发现词语的问题,计算问题和集中问题的主观记忆投诉。参与者根据血清25OHD的最高三分位数(即≥68nmol/ L)进行分类。将年龄,性别,体重指数,疾病负担,维生素D补充剂的使用,认知表现,情绪,血钙浓度,甲状旁腺激素和维生素B12,肌酸酐清除率和评估季节用作潜在混杂因素。 结果:与25OHD <68nmol / L(n = 121)的受试者相比,25OHD≥68nmol/ L的患者学习新信息的问题较少(P = 0.027)。其他记忆投诉没有组间差异。即使调整了潜在的混杂因素(OR = 0.32,P = 0.039),25OHD最高的三分位数在横断面上与更少的学习新信息的问题相关(比值比(OR)= 0.48,P = 0.029)。 结论:较高的维生素D状态与记忆老年社区居民新信息的问题减少有关。这项新发现为试图改善老年患者认知能力下降的主观体验的维生素D替代试验提供了科学依据。
关键词: 认知,痴呆,学习,主观记忆投诉,神经内分泌学,老年人,维生素D.
Current Alzheimer Research
Title:Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults
Volume: 15 Issue: 7
关键词: 认知,痴呆,学习,主观记忆投诉,神经内分泌学,老年人,维生素D.
摘要: Background: Older adults with hypovitaminosis D report more often subjective cognitive complaints, especially with regards to memory. This raises prospects that vitamin D may improve older adults' subjective experience of memory disorders.
Objective: To determine among older community-dwellers whether higher serum 25- hydroxyvitamin D (25OHD) concentrations were associated with fewer memory complaints, while considering different subtypes of memory complaints.
Method: One hundred eighty Caucasian community-dwellers with memory complaint and no dementia (mean±standard deviation, 71.1±3.4years; 33.3%female) from the French ‘EVATEM study' were included in this analysis. Subjective memory complaints regarding memory lapses, problems learning new information, problems finding words, problems calculating and problems concentrating were assessed using a standardized questionnaire. Participants were categorized according to the highest tertile of serum 25OHD (i.e., ≥68nmol/L). Age, gender, body mass index, morbidities burden, use of vitamin D supplements, cognitive performance, mood, serum concentrations of calcium, parathyroid hormone and vitamin B12, creatinine clearance, and season of evaluation were used as potential confounders.
Results: Compared to participants with 25OHD<68nmol/L (n=121), those with 25OHD≥68nmol/L had less often problems learning new information (P=0.027). There were no between-group differences for the other memory complaints. The highest 25OHD tertile was cross-sectionally associated with fewer problems learning new information (odds ratio (OR)=0.48, P=0.029), even after adjustment for potential confounders (OR=0.32, P=0.039).
Conclusion: Higher vitamin D status was associated with reduced problems memorizing new information in older community-dwellers. This novel finding provides a scientific base for vitamin D replacement trials attempting to improve older patients' subjective experience of cognitive decline.
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Cite this article as:
Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults, Current Alzheimer Research 2018; 15 (7) . https://dx.doi.org/10.2174/1567205015666180201153735
DOI https://dx.doi.org/10.2174/1567205015666180201153735 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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