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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Functionalized Ionic Liquids as New Supports for Peptide Coupling and Traceless Catalyzed Carbon-Carbon Coupling Reactions

Author(s): Fabien Bonnette, Zoia Mincheva and Olivier Lavastre

Volume 9, Issue 3, 2006

Page: [229 - 232] Pages: 4

DOI: 10.2174/138620706776055485

Price: $65

Abstract

A new strategy to obtain pure ionic liquid support with a high loading (3 mmol/g) of primary amino groups is reported. The compatibility of the imidazolium unit was demonstrated with DIC or DCC coupling reactions of protected amino acids and with classical cleavage of BOC or Fmoc protecting groups. In addition, this is the first report of a traceless ionic liquid support based on a silicon linker with a high loading (3 mmol/g) of aryl bromide reactive groups used in a palladium-catalyzed carbon-carbon coupling reaction.

Keywords: Ionic liquids support, coupling reactions


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