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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Review Article

Synthesis of Secondary Phosphine Oxides by Substitution at Phosphorus by Grignard Reagents

Author(s): Anna Tripolszky and Gyorgy Keglevich*

Volume 15, Issue 5, 2018

Page: [387 - 393] Pages: 7

DOI: 10.2174/1570178615666171227144555

open access plus


Secondary phosphine oxides (SPOs) are important starting materials in organophosphorus syntheses, and may be the ligands in transition metal complexes. SPOs are obtained from phosphorus trichloride via double substitution by a Grignard reagent followed by hydrolysis, or from dialkyl phosphites by reaction with two equivalents of a Grignard reagent. The preparation of SPOs with two different substituents is of special importance. This minireview gives useful hints for the synthesis of a variety of SPOs that are useful intermediates.

Keywords: Dialkyl phosphites, grignard reagents, P(III)-chlorides, secondary phosphine oxides, substitution, ligand.

Graphical Abstract

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