DBU-Assisted Cyclorelease Elimination: Combinatorial Synthesis and γ- Glutamyl Cysteine Synthetase and Glutathione-S-Transeferase Modulatory Effect of C-Nucleoside Analogs

Title: DBU-Assisted Cyclorelease Elimination: Combinatorial Synthesis and γ- Glutamyl Cysteine Synthetase and Glutathione-S-Transeferase Modulatory Effect of C-Nucleoside Analogs

Volume: 6 Issue: 1

Author(s): R. C. Mishra, Neetu Tewari, Kavita Arora, Rumana Ahmad, R. P. Tripathi, V. K. Tiwari, R. D. Walter and A. K. Srivastava

Affiliation:

Keywords: cyclorelease elimination, c- nucleosides, combinatorial synthesis, diazabicyclo (5.4.0) undec-7-ene, glutamyl cysteine synthetase, glutathione-s- transeferase, dihydropyrimidinones

Abstract: A combinatorial library of 60 C- nucleoside analogs was synthesized by sequential coupling of building blocks followed by cyclative cleavage with DBU in an efficient manner. Only DMSO soluble compounds were tested for their modulatory effect against filarial γ-glutamyl cysteine synthetase (γ-GCase) and glutathione-S-transeferases (GSTs). Several compounds were found to be weak inhibitors of filarial γ-GCase, whereas, most of them stimulated filarial GSTs.

Cite this article as:

Mishra C. R., Tewari Neetu, Arora Kavita, Ahmad Rumana, Tripathi P. R., Tiwari K. V., Walter D. R. and Srivastava K. A., DBU-Assisted Cyclorelease Elimination: Combinatorial Synthesis and γ- Glutamyl Cysteine Synthetase and Glutathione-S-Transeferase Modulatory Effect of C-Nucleoside Analogs, Combinatorial Chemistry & High Throughput Screening 2003; 6 (1) . https://dx.doi.org/10.2174/1386207033329887