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Current Microwave Chemistry

Editor-in-Chief

ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

Research Article

Copper Catalyzed Ligand Free Microwave Mediated Synthesis of α-ketoamides from Aromatic Ketones

Author(s): Kshipra S. Karnik, Aniket P. Sarkate, Shritesh D. Jagtap and Pravin S. Wakte*

Volume 5 , Issue 1 , 2018

Page: [39 - 45] Pages: 7

DOI: 10.2174/2213335604666171128150721

Price: $65

Abstract

Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for α- ketoamides has been developed by using secondary amines.

Methods: In the synthetic method, the targeted α-ketoamides were synthesized with the help of microwave by reacting secondary amines and aryl methyl ketones in the presence of copper chloride and hydrogen peroxide.

Results: α-ketoamides were prepared in good yields (within 10mins) with the help of a microwave irradiation. The reported protocol is ligand free and the yields of the derivatives were modest to excellent.

Conclusion: Microwave assisted technique will be a useful alternative method for the preparation of α-ketoamides.

Keywords: Aryl methyl ketones, copper chloride, microwave, secondary amines, α-ketoamides, synthetic protocol.

Graphical Abstract

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