Abstract
TB is one of the major infectious diseases caused by Mycobacterium tuberculosis (M.TB) with millions of people dying every year. Emergence of new cases, increased incidence of multi drug resistant strains of M.TB and the adverse effects of first and second line antitubercular drugs have led to renewed interest in natural products with the hope of discovering new antitubercular leads. Coumarins and chalcones are plant derived secondary metabolites with potentially exploitable activities against M.TB. To pave way for future antitubercular research, there is an urgent need to collect latest information on these promising moieties. The objective of this review is to focus on the newer and important coumarin and chalcone derivatives having potent antitubercular activity. General scheme of synthesis of coumarins and chalcones is presented. This review enlightens the landscape of the discovery and development of chalcones and coumarin based antitubercular drugs with an emphasis on Structure- Activity Relationship (SAR) and inhibition of some their specific molecular targets. We hope that this review paper would provide new opportunities for researchers to design future generation novel and potent coumarin and chalcone based antitubercular drugs with higher activity and lesser toxicity.
Keywords: Antitubercular activity, Mycobacterium tuberculosis, QSAR Studies, Molecular targets, Chalcones, Coumarins.
Graphical Abstract
Call for Papers in Thematic Issues
An Overview of Drugs for Multiple Targets and Variants of SARS-CoV-2 Through Artificial Intelligence, Machine Learning, Deep Learning, and Experimental Analysis
The emergence and rapid evolution of SARS-CoV-2 variants have posed significant challenges in the ongoing fight against the COVID-19 pandemic. The development of effective treatments for multiple viral targets and variants demands innovative approaches, including artificial intelligence (AI), machine learning (ML), and deep learning (DL) techniques. This special issue aims ...read more
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