摘要
背景:氧化应激是轻度认知功能障碍(MCI)和痴呆等神经退行性疾病的发病机制之一。我们之前报道过空化氢(H2)是一种治疗性和预防性的抗氧化剂。 目的:观察饮用H2-水(含H2的水)对氧化应激模型小鼠和MCI受试者的影响。 方法:用表达乙醛脱氢酶2显性负型的转基因小鼠作为痴呆模型。强化氧化应激小鼠可饮用H2水。对于类风湿性关节炎73例MCI患者每日饮用~300 mL H2-水(H2-组)或安慰剂水(对照组),并进行阿尔茨海默病评估量表(Scal)。1年后测定电子认知分量表(ADAS-COG)得分. 结果:饮用H2-水可降低小鼠的氧化应激指标,抑制记忆障碍和神经退行性变。此外,H2-水组的平均寿命较长。ER组优于对照组。在MCI患者中,h2组与对照组ADAS-COG评分1年后差异无显着性,但载脂蛋白E4(A)H2组POE 4基因型在ADAS-COG总分和单词回忆任务评分(ADAS-COG分中的一个子分)上有显著改善。 结论:H2-水在氧化应激模型和APOE4载体MCI中可能具有抑制痴呆的作用。
关键词: ADAS-COG评分,醛脱氢酶2,ApoE 4,氢,氢水,轻度认知障碍,氧化应激,随机临床研究。
Current Alzheimer Research
Title:Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
Volume: 15 Issue: 5
关键词: ADAS-COG评分,醛脱氢酶2,ApoE 4,氢,氢水,轻度认知障碍,氧化应激,随机临床研究。
摘要: Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant.
Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI.
Methods: Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model. The mice with enhanced oxidative stress were allowed to drink H2-water. For a randomized double-blind placebo-controlled clinical study, 73 subjects with MCI drank ~300 mL of H2-water (H2-group) or placebo water (control group) per day, and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scores were determined after 1 year.
Results: In mice, drinking H2-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. Moreover, the mean lifespan in the H2-water group was longer than that of the control group. In MCI subjects, although there was no significant difference between the H2- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H2-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score).
Conclusion: H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI.
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Cite this article as:
Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment, Current Alzheimer Research 2018; 15 (5) . https://dx.doi.org/10.2174/1567205014666171106145017
DOI https://dx.doi.org/10.2174/1567205014666171106145017 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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