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Current Immunology Reviews (Discontinued)

Editor-in-Chief

ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Review Article

Immunomodulatory Effects of Vitamin D in Influenza Infection

Author(s): Ramazan Rezaei, Saeed Aslani, Mahdi Marashi, Farhad Rezaei and Ehsan Sharif-Paghaleh*

Volume 14 , Issue 1 , 2018

Page: [40 - 49] Pages: 10

DOI: 10.2174/1573395513666171031162100

Price: $65

Abstract

Background: Vitamin D has mainly been described in the literature beyond its skeletal functions, including an influence on the immune responses against infections. Observational and interventional studies have represented evidence that Vitamin D deficiency may cause increased risk of seasonal influenza and pulmonary tract infection.

Methods: A structured search of EMBASE, Medline, and Web of Science databases was fulfilled to extract all eligible articles published prior to September 2017.

Results: In this review, our goal is to define the possible mechanisms that link influenza-mediated immune responses to Vitamin D. Herein, we first briefly describe the role of Vitamin D in the immune responses and then elucidate three immunological processes that connect Vitamin D to influenza infection. Finally, we describe randomized controlled trials and observational studies exploring the effect of Vitamin D supplementation on seasonal influenza infections and vaccinations.

Conclusion: Our literature review suggests that treatment of influenza-infected individuals with Vitamin D supplements or cathelicidin-derived agents may provide appreciable protection against natural influenza infection. Moreover, Vitamin D given at appropriate doses may facilitate protection against seasonal flu.

Keywords: Vitamin D, influenza virus, infection, immune response, infection, immunomodulatory effect.

Graphical Abstract

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