Abstract
This is a review of recent progress in developing biocatalytic reactions involving two major groups of phenol oxidases, viz., laccases (benzenediol:oxygen oxidoreductase E.C. 1.10.13.2) and polyphenol oxidases (phenol: oxygen oxidoreductase, E.C. 1.14.18.1, also known as tyrosinase). Oxidases catalyse reactions involving direct activation of oxygen, and within this group, the multi-copper oxidases catalyse the four-electron reduction of oxygen to water with the concomitant one-electron oxidation of a substrate. Such reactions, applied in biocatalytic systems, provide effective methods to achieve oxyfunctionalisation, (particularly asymmetric oxyfunctionalisation reactions) and routes to controlled and predictable formation of oxy- and hydroxylated products, and polymers. The review includes discussion of the characteristics of these enzymes which are of relevance to their application as biocatalysts.
Keywords: Laccases, Phenol Oxidases, oxyfunctionalisation, hydroxylated products, biocatalysts
Current Organic Chemistry
Title: Laccases and Phenol Oxidases in Organic Synthesis - a Review
Volume: 7 Issue: 13
Author(s): Stephanie G. Burton
Affiliation:
Keywords: Laccases, Phenol Oxidases, oxyfunctionalisation, hydroxylated products, biocatalysts
Abstract: This is a review of recent progress in developing biocatalytic reactions involving two major groups of phenol oxidases, viz., laccases (benzenediol:oxygen oxidoreductase E.C. 1.10.13.2) and polyphenol oxidases (phenol: oxygen oxidoreductase, E.C. 1.14.18.1, also known as tyrosinase). Oxidases catalyse reactions involving direct activation of oxygen, and within this group, the multi-copper oxidases catalyse the four-electron reduction of oxygen to water with the concomitant one-electron oxidation of a substrate. Such reactions, applied in biocatalytic systems, provide effective methods to achieve oxyfunctionalisation, (particularly asymmetric oxyfunctionalisation reactions) and routes to controlled and predictable formation of oxy- and hydroxylated products, and polymers. The review includes discussion of the characteristics of these enzymes which are of relevance to their application as biocatalysts.
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Cite this article as:
Burton G. Stephanie, Laccases and Phenol Oxidases in Organic Synthesis - a Review, Current Organic Chemistry 2003; 7 (13) . https://dx.doi.org/10.2174/1385272033486477
DOI https://dx.doi.org/10.2174/1385272033486477 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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