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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Fluorescein-Inspired Near-Infrared Chemodosimeter for Luminescence Bioimaging

Author(s): Hai-Yan Wang, Huisheng Zhang, Siping Chen* and Yi Liu *

Volume 26 , Issue 21 , 2019

Page: [4029 - 4041] Pages: 13

DOI: 10.2174/0929867324666171024101715

Price: $65


Luminescence bioimaging is widely used for noninvasive monitoring of biological targets in real-time with high temporal and spatial resolution. For efficient bioimaging in vivo, it is essential to develop smart organic dye platforms. Fluorescein (FL), a traditional dye, has been widely used in the biological and clinical studies. However, visible excitation and emission limited their further application for in vivo bioimaging. Nearinfrared (NIR) dyes display advantages of bioimaging because of their minimum absorption and photo-damage to biological samples, as well as deep tissue penetration and low auto-luminescence from background in the living system. Thus, some great developments of near-infrared fluorescein-inspired dyes have emerged for bioapplication in vitro and in vivo. In this review, we highlight the advances in the development of the near-infrared chemodosimeters for detection and bioimaging based on the modification of fluoresceininspired dyes naphtho-fluorescein (NPF) and cyanine-fluorescein (Cy-FL).

Keywords: Near Infrared, naphtho-fluorescein, cyanine-fluorescein, luminescence, chemodosimeter, bioimaging.

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