Abstract
Background: Under the transcriptional control of numerous factors and intracellular signals, mesenchymal stem cells (MSCs) can differentiate into various cell types, including adipocytes and osteoblasts. However, the precise cellular signaling factors that determine the cell fate of MSCs in bone marrow remain largely unknown.
Objective: In this review, we focus on the ties of PPAR-γ and Wnt signaling in MSC differentiation into adipocytes and osteoblasts.
Results: Peroxisome proliferator-activated receptor-γ (PPAR-γ) is well established as a prime inducer of adipogenesis, while the Wnt pathway is regarded as the master moderator of osteogenesis. A theoretical inverse relationship exists between adipogenic and osteogenic lineage commitment and differentiation: the differentiation toward an osteoblast phenotype occurs at the expense of an adipocyte phenotype.
Conclusion: It has been proposed that the balance between osteogenic and adipogeneic MSC differentiation is disrupted in diverse areas of human health. Therefore, understanding the ties between PPAR- γand Wnt signaling in MSC differentiation has significant implications in diverse areas of human health, from obesity to osteoporosis to regenerative medicine.
Keywords: PPAR-γ, Wnt, adipocyte, osteoblast, MSCs, differentiation.
Current Stem Cell Research & Therapy
Title:PPAR-γ and Wnt Regulate the Differentiation of MSCs into Adipocytes and Osteoblasts Respectively
Volume: 13 Issue: 3
Author(s): Yue Li, Daxiang Jin*, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding and Dongcheng Ren
Affiliation:
- The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou,China
Keywords: PPAR-γ, Wnt, adipocyte, osteoblast, MSCs, differentiation.
Abstract: Background: Under the transcriptional control of numerous factors and intracellular signals, mesenchymal stem cells (MSCs) can differentiate into various cell types, including adipocytes and osteoblasts. However, the precise cellular signaling factors that determine the cell fate of MSCs in bone marrow remain largely unknown.
Objective: In this review, we focus on the ties of PPAR-γ and Wnt signaling in MSC differentiation into adipocytes and osteoblasts.
Results: Peroxisome proliferator-activated receptor-γ (PPAR-γ) is well established as a prime inducer of adipogenesis, while the Wnt pathway is regarded as the master moderator of osteogenesis. A theoretical inverse relationship exists between adipogenic and osteogenic lineage commitment and differentiation: the differentiation toward an osteoblast phenotype occurs at the expense of an adipocyte phenotype.
Conclusion: It has been proposed that the balance between osteogenic and adipogeneic MSC differentiation is disrupted in diverse areas of human health. Therefore, understanding the ties between PPAR- γand Wnt signaling in MSC differentiation has significant implications in diverse areas of human health, from obesity to osteoporosis to regenerative medicine.
Export Options
About this article
Cite this article as:
Li Yue , Jin Daxiang *, Xie Weixing , Wen Longfei , Chen Weijian , Xu Jixi , Ding Jinyong and Ren Dongcheng , PPAR-γ and Wnt Regulate the Differentiation of MSCs into Adipocytes and Osteoblasts Respectively, Current Stem Cell Research & Therapy 2018; 13 (3) . https://dx.doi.org/10.2174/1574888X12666171012141908
DOI https://dx.doi.org/10.2174/1574888X12666171012141908 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Modulating the Amyloidogenesis of α-Synuclein
Current Neuropharmacology Breast Cancer: Understanding Sensitivity and Resistance to Chemotherapy and Targeted Therapies to Aid in Personalised Medicine
Current Cancer Drug Targets Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy
Current Pharmaceutical Design Editorial [Hot Topic:Positron Emission Tomography (PET) in Medicinal Chemistry and Drug Discovery (Guest Editor: Ming-Rong Zhang)]
Current Topics in Medicinal Chemistry Status of Acetylcholinesterase and Butyrylcholinesterase in Alzheimer's Disease and Type 2 Diabetes Mellitus
CNS & Neurological Disorders - Drug Targets The Risk That DSM-5 Will Promote Even More Inappropriate Antipsychotic Exposure In Children and Teenagers
Current Psychiatry Reviews Reactive Oxygen and Nitrogen Species in Alzheimers Disease
Current Alzheimer Research Microwave Controlled the Green Synthesis of Acrylamide Graft Copolymers of Azadirachita indica Gum for the Wastewater Management
Current Applied Polymer Science Evidences of Brain Plasticity and Motor Control Modulation after Hemodialysis Session by Helixone Membrane: BOLD-fMRI Study
CNS & Neurological Disorders - Drug Targets Longitudinal Neuropsychological Outcome in Taiwanese Alzheimer's Disease Patients Treated with Medication
Current Alzheimer Research Levodopa in Parkinson’s Disease: Current Status and Future Developments
Current Neuropharmacology Metabolomics Analysis for Biomarker Discovery: Advances and Challenges
Current Medicinal Chemistry Glycosylation Pathways as Drug Targets for Cancer: Glycosidase Inhibitors
Mini-Reviews in Medicinal Chemistry Zinc Hydrogen Sulfate Promoted Multi-component Preparation of Highly Functionalized Piperidines
Letters in Organic Chemistry Diagnosis of Mild Cognitive Impairment Using Cognitive Tasks: A Functional Near-Infrared Spectroscopy Study
Current Alzheimer Research OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease
Current Immunology Reviews (Discontinued) Homocysteine, Intracellular Signaling and Thrombotic Disorders
Current Medicinal Chemistry Real Time Analysis of Neurotransmitters in the Brain Using a Micro-Electrode System
Current Neurovascular Research CYP4 Enzymes As Potential Drug Targets: Focus on Enzyme Multiplicity, Inducers and Inhibitors, and Therapeutic Modulation of 20- Hydroxyeicosatetraenoic Acid (20-HETE) Synthase and Fatty Acid ω- Hydroxylase Activities
Current Topics in Medicinal Chemistry The Value of Neuroimaging Techniques in the Translation and Transdiagnostic Validation of Psychiatric Diagnoses - Selective Review
Current Topics in Medicinal Chemistry