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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Biomarkers of Atrial Fibrillation in Metabolic Syndrome

Author(s): Christos Georgakopoulos, Charalambos Vlachopoulos*, Georgios Lazaros and Dimitrios Tousoulis

Volume 26 , Issue 5 , 2019

Page: [898 - 908] Pages: 11

DOI: 10.2174/0929867324666171012105528

Price: $65


Whether the increased atrial fibrillation (AF) risk in metabolic syndrome (MetS) patients is due to the syndrome as a whole or simply the sum of the risks of its individual component parts is still obscure. These two clinical entities share many pathophysiological links and thus distinction between a casual observation and a significant association is difficult. Biomarkers associated with pathogenesis of AF in the context of MetS have the ability to refine future risk prediction. In the present review we identify circulating substances that could be regarded as potential biomarkers for prediction of incident AF, or of cardiovascular events in the setting of AF in patients with MetS. Cardiac myocyte injury and stress markers (troponin and natriuretic peptides), markers of renal function (glomeral filtration rate, cystatin-C), and inflammation markers/mediators (interleukin- 6, CRP) are promising biomarkers of patients with AF and MetS.

Keywords: Biomarkers, Atrial fibrillation, Metabolic Syndrome, Troponin, BNP, GFR, Cystatin-C, Kidney disease, CRP, IL-6, Inflammation.

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