Triazino-caffeine Derivatives by Intramolecular Cyclization: Synthesis, Characterization and Antimicrobial Studies

Title:Triazino-caffeine Derivatives by Intramolecular Cyclization: Synthesis, Characterization and Antimicrobial Studies

Volume: 15 Issue: 6

Author(s): A.B. Reddy*, R.V. Hymavathi, G.N. Swamy and E.R. Sadiku

Affiliation:

• Department of Chemical, Metallurgical and Materials Engineering, Tshwane University of Technology, Pretoria Campus, Building 2, Pretoria,south africa

Keywords: Triazino-caffeine derivatives, Mitsunobu reaction, intramolecular cyclization, antimicrobial activities, morpholine moiety, heterocycles.

Abstract: In the present study, a new class of triazino-caffeine derivatives with good antimicrobial activities is reported. Eight new triazino-caffeine derivatives were synthesized via Mitsunobu reaction, followed by intramolecular cyclization. Their chemical structures were established on the basis of elemental analysis, IR, 1H NMR, mass spectral data as well as through an alternate synthetic route. The compounds were also screened for their antimicrobial activities, among them, compounds 5c and 5d showed good inhibitory potentials, indicating the importance of morpholine moiety in enhancing antimicrobial activity. Therefore, it is concluded that the triazino-caffeine derivatives developed, show encouraging potentials in their medicinal applications.

Cite this article as:

Reddy A.B. *, Hymavathi R.V. , Swamy G.N. and Sadiku E.R. , Triazino-caffeine Derivatives by Intramolecular Cyclization: Synthesis, Characterization and Antimicrobial Studies, Letters in Organic Chemistry 2018; 15 (6) . https://dx.doi.org/10.2174/1570178614666171010161357