Multi-Target Metal-Based Anticancer Agents

Title:Multi-Target Metal-Based Anticancer Agents

Volume: 17 Issue: 28

Author(s): Zhen-Feng Chen*, Chris Orvig and Hong Liang*

Affiliation:

• State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004,China

• State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004,China

Keywords: Multi-target, metal complexes, cytotoxicity, anticancer agents, nickel complexes, pathogenic factors.

Abstract: There has been a growing interest in the rational design of multi-targeted drugs with the aim of enhancing overall efficacy and/or improving safety. The development of multi-targeted drugs might yield new avenues in the treatment of cancers that involve multiple pathogenic factors. In this review, we focus on the multi-targeted metal-based anticancer agents, which include platinum, ruthenium, rhodium, gold, silver, copper, cobalt, zinc, and nickel complexes. Future directions for the development of multi-targeted metal-based anticancer agents are also proposed.

Cite this article as:

Chen Zhen-Feng *, Orvig Chris and Liang Hong *, Multi-Target Metal-Based Anticancer Agents, Current Topics in Medicinal Chemistry 2017; 17(28) . https://dx.doi.org/10.2174/1568026617666171004155437