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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Multi-Target Metal-Based Anticancer Agents

Author(s): Zhen-Feng Chen*, Chris Orvig and Hong Liang*

Volume 17, Issue 28, 2017

Page: [3131 - 3145] Pages: 15

DOI: 10.2174/1568026617666171004155437

Price: $65


There has been a growing interest in the rational design of multi-targeted drugs with the aim of enhancing overall efficacy and/or improving safety. The development of multi-targeted drugs might yield new avenues in the treatment of cancers that involve multiple pathogenic factors. In this review, we focus on the multi-targeted metal-based anticancer agents, which include platinum, ruthenium, rhodium, gold, silver, copper, cobalt, zinc, and nickel complexes. Future directions for the development of multi-targeted metal-based anticancer agents are also proposed.

Keywords: Multi-target, metal complexes, cytotoxicity, anticancer agents, nickel complexes, pathogenic factors.

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