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Current Enzyme Inhibition

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ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Research Article

In vitro Evaluation of Helicobacter pylori and Ureases Inhibition Activity of Syrian Honey Samples

Author(s): Wissam Zam*, Aziz Khaddour and Hala Suliman

Volume 14 , Issue 2 , 2018

Page: [146 - 151] Pages: 6

DOI: 10.2174/1573408013666170929122514

Price: $65

Sekisui-XenoTech-CEI
Abstract

Background: It has been considered that Helicobacter pylori, a bacterium associated with a number of important upper gastrointestinal conditions cannot always effectively eradicated by the traditional approaches; however, there some alternative therapies have been presented. Honey has been used as a medicine since ancient times in many countries for its elevated antioxidant activity, as well as expressive antimicrobial activity.

Objective: the objective of this study was to investigate the effecting degree of H. pylori with different type of honey samples from Syria.

Methods: micro-dilution method and agar-well diffusion assay were carried out on H. pylori isolated from gastric biopsy. Inhibition of H. pylori urease was also tested.

Results: all honey samples inhibited the growth of H. pylori with a MIC ranging from 30-50%. Both Black seed honey and Coastal Mountain honeys at 50% (v/v%) showed a growth inhibition zone of 16 and 15 mm, respectively; being similar to the growth inhibition zone of Amoxicillin (15 mm) and Levofloxacin (14 mm). 65% of H. pylori urease activity was inhibited using Black seed honey and Coastal Mountain at 50% (v/v%).

Conclusion: These results indicate that Black seed and Coastal Mountain honey samples may be appropriate agents to treat H. pylori.

Keywords: Helicobacter pylori, inhibition zone diameter, MIC, syrian honey samples, urease inhibition, colonization.

Graphical Abstract

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