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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

The Tandem Claisen Rearrangement in Organic Synthesis

Author(s): Xueqin Zhang , Gangliang Huang * and Siqi Huang

Volume 21 , Issue 27 , 2017

Page: [2776 - 2782] Pages: 7

DOI: 10.2174/1385272821666170927162859

Price: $65


Background: Claisen rearrangement is an important reaction, and some "variants" are brought out under the inspiration of Claisen reaction, e.g. Bellus-Claisen rearrangement, Eschenmoser-Claisen rearrangement, Ireland-Claisen rearrangement, and Johnson-Claisen rearrangement.

Objective: The application of tandem Claisen rearrangement in organic synthesis was analyzed and discussed herein.

Method: We chose some important synthetic studies utilizing the tandem Claisen rearrangement as the key transformation and concisely described and discussed their contents.

Results: The tandem reaction could shorten the reaction steps and improve the reaction yield.

Conclusion: So, the tandem Claisen rearrangement would greatly improve the efficiency of reaction.

Keywords: Tandem Claisen rearrangement, variants, organic synthesis, reaction step, efficiency, application.

Graphical Abstract

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