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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology

Author(s): Jignesh Lunagariya, Poonam Bhadja, Shenghui Zhong, Rohit Vekariya and Shihai Xu*

Volume 19, Issue 9, 2019

Page: [751 - 761] Pages: 11

DOI: 10.2174/1389557517666170927154231

Price: $65


Marine bis-indole alkaloids comprise a large and increasingly growing class of secondary metabolites, and continue to deliver a great variety of structural templates for diverse biological targets. The alkaloids derived from marine resources play a crucial role in medicinal chemistry and as chemical agents. In particular, bis-indole alkaloid caulerpin which has been isolated from marine green algae Caulerpa and a red algae Chondria armata at various places around the world, was tested for several therapeutic potentials such as anti-diabetic, antinociceptive, anti-inflammatory, anti-tumor, anti- larvicidal, anti-herpes, anti-tubercular, anti-microbial and immunostimulating activities as well as a means of other chemical agents. Herein, we summarized the discovery and isolation of caulerpin, and its potential medicinal and chemical applications in chronological order with various aspects. Additionally, synthesis of caulerpin and its functional analogues have also been reviewed.

Keywords: Bis-indole alkaloid, caulerpin, biological activity, marine natural product, total synthesis, secondary metabolites.

Graphical Abstract
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