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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Current Progress in the Chemistry and Pharmacology of Akuammiline Alkaloids

Author(s): Antonio Ramirez and Silvina Garcia-Rubio

Volume 10 , Issue 18 , 2003

Page: [1891 - 1915] Pages: 25

DOI: 10.2174/0929867033457016

Price: $65


Akuammiline alkaloids are a family of monoterpene indole alkaloids of renewed medicinal interest. These bases act as ligands for a heterogeneous group of molecular targets and, consequently, display a wide variety of pharmacological activities. For example, pseudoakuammigine (2) exhibits opioid activity in vivo, echitamine (4) has been reported to have promising cytotoxic activity, and corymine (121) behaves as an antagonist of the glycine receptor. Oddly enough, these alkaloids have not raised enough interest in the organic synthesis community, remaining inaccessible; even the entry to their pentacyclic framework continues elusive. Recently, several akuammiline bases have been isolated and identified including bisindole alkaloids, such as vingramine (103) or rausutrine (110), which incorporate akuammiline-type subunits. This review covers the advances in the chemistry and pharmacology of akuammiline alkaloids reported within the last ten years.

Keywords: akuammiline, bisindole, echitamine, indole, isolation, monoterpene alkaloids, pharmacology, strictamine

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