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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Design and Development of Integrase Inhibitors as Anti-HIV Agents

Author(s): S. P. Gupta and A. N. Nagappa

Volume 10 , Issue 18 , 2003

Page: [1779 - 1794] Pages: 16

DOI: 10.2174/0929867033456972

Price: $65


A review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides (double-stranded, triplex, and G-quartet), curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl - based compounds, hydrazides and amides, tetracyclines, and depsides and depsidones. For all these compounds, the important structural features essential for the inhibition of the integrase are pointed out.

Keywords: integrase inhibitors, hiv-1 integrase, oligonucleotides, double-stranded

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