摘要
几个世纪以来,植物化学物质已被用于预防和治疗多种健康疾病。据报道,植物化学物具有抗氧化,抗糖尿病,镇咳,抗寄生虫,抗癌和抗微生物性质。一般而言,植物化学物质的治疗用途是基于传统或口头报告,很少有证据为基础的研究。而且,大多数植物化学物质的分子水平相互作用或分子靶标是未知的。近年来,微生物对抗生素的抗药性已成为一个重要的医疗保健问题。因此,具有抗微生物特性的植物化学品的使用已变得相关。来自植物,蔬菜,香草和香料的天然化合物具有很强的抗菌性能,为预防和抗击抗生素抗性微生物感染提供了极好的机会。 ATP合酶是细胞能量的基本手段。 ATP合酶的抑制可能导致细胞所需的能量导致细胞死亡,并且已知多种饮食植物化学物质抑制ATP合酶。已经显示植物化学物质的结构修饰增加了抑制效力和抑制程度。定点诱变分析已经阐明了一些植物化学物质对ATP合酶的结合位点。植物化学物质结合位点及其周围的氨基酸变异可导致微生物ATP合酶的选择性结合和抑制。在这篇综述中,膳食植物化学物质与ATP合成酶之间的治疗联系是基于饮食植物化学物质对ATP合酶的抑制作用。研究表明ATP合酶的选择性靶向是抗击抗生素抗性微生物感染的有价值的替代分子水平方法。
关键词: 微生物和哺乳动物F1Fo三磷酸腺苷合酶,抗菌植物化学物质,多酚,酶抑制剂,分子药物靶点。
Current Medicinal Chemistry
Title:A Therapeutic Connection between Dietary Phytochemicals and ATP Synthase
Volume: 24 Issue: 35
关键词: 微生物和哺乳动物F1Fo三磷酸腺苷合酶,抗菌植物化学物质,多酚,酶抑制剂,分子药物靶点。
摘要: For centuries, phytochemicals have been used to prevent and cure multiple health ailments. Phytochemicals have been reported to have antioxidant, antidiabetic, antitussive, antiparasitic, anticancer, and antimicrobial properties. Generally, the therapeutic use of phytochemicals is based on tradition or word of mouth with few evidence-based studies. Moreover, molecular level interactions or molecular targets for the majority of phytochemicals are unknown. In recent years, antibiotic resistance by microbes has become a major healthcare concern. As such, the use of phytochemicals with antimicrobial properties has become pertinent. Natural compounds from plants, vegetables, herbs, and spices with strong antimicrobial properties present an excellent opportunity for preventing and combating antibiotic resistant microbial infections. ATP synthase is the fundamental means of cellular energy. Inhibition of ATP synthase may deprive cells of required energy leading to cell death, and a variety of dietary phytochemicals are known to inhibit ATP synthase. Structural modifications of phytochemicals have been shown to increase the inhibitory potency and extent of inhibition. Sitedirected mutagenic analysis has elucidated the binding site(s) for some phytochemicals on ATP synthase. Amino acid variations in and around the phytochemical binding sites can result in selective binding and inhibition of microbial ATP synthase. In this review, the therapeutic connection between dietary phytochemicals and ATP synthase is summarized based on the inhibition of ATP synthase by dietary phytochemicals. Research suggests selective targeting of ATP synthase is a valuable alternative molecular level approach to combat antibiotic resistant microbial infections.
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A Therapeutic Connection between Dietary Phytochemicals and ATP Synthase, Current Medicinal Chemistry 2017; 24 (35) . https://dx.doi.org/10.2174/0929867324666170823125330
DOI https://dx.doi.org/10.2174/0929867324666170823125330 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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