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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Research Article

Organic Reactions under High Pressure: Efficient Multicomponent Synthesis of Novel Tricyclic Pyridazinonaphthyridine Derivatives under High Pressure

Author(s): Moustafa S. Moustafa and Saleh M. Al-Mousawi*

Volume 22, Issue 3, 2018

Page: [268 - 275] Pages: 8

DOI: 10.2174/1385272821666170817105019

Price: $65

Abstract

Background and Methodology: A series of pyridazino[5,4,3-de][1,6]naphthyridine derivatives of a new ring system (11a-k, 29a,b) were synthesized via novel multicomponent reaction under high pressure from 2-phenylhydrazono derivatives (1a-d), malononitrile and aromatic aldehydes (10a-h) or acetone (28).

Conclusion: The structure of reaction products could be established by X-ray crystallography and a mechanism of reaction is proposed.

Keywords: Multi component reactions, reactions under pressure, hetero-tricyclic systems, 2- phenylhydrazones, aldehydes, acetone.

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