Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma

Title:Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma

Volume: 24 Issue: 9

Author(s): Carlos Alberto de Carvalho Fraga, Lucyana Conceicao Farias, Kimberly Marie Jones, Alfredo Mauricio Batista de Paula and Andre Luiz Sena Guimaraes*

Affiliation:

• Universidade Estadual de Montes Claros. Hospital Universitario Clemente Faria. Laboratorio de Pesquisa em Saude, 562 Av. Cula Mangabeira Santo Expedito. Montes Claros, MG,Brazil

Keywords: Head and neck cancer, obesity, Angiogenesis, ACE, Ang 1-7, angiotensin-converting enzyme.

Abstract: Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.

Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia, specifically for Oral Squamous Cell Carcinoma (OSCC).

Conclusion: The literature review and Bioinformatics analyses showed that ACE and ACE2 are interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged for experimental validation.

Cite this article as:

de Carvalho Fraga Alberto Carlos , Farias Conceicao Lucyana, Jones Marie Kimberly, Batista de Paula Mauricio Alfredo and Guimaraes Luiz Sena Andre *, Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma, Protein & Peptide Letters 2017; 24(9) . https://dx.doi.org/10.2174/0929866524666170815161621