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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

A One-Pot Multicomponent Synthesis of Naphthoxazin-3-one Derivatives Using Amberlite IRA-400 Cl Resin as Green Catalyst

Author(s): Gurusamy Harichandran*, Parkunan Parameswari and Ponnusamy Shanmugam

Volume 15 , Issue 7 , 2018

Page: [600 - 605] Pages: 6

DOI: 10.2174/1570178614666170811151040

Price: $65


An efficient Amberlite IRA-400 Cl resin catalyzed, solvent-free, one-pot synthesis of 1- aryl-1,2-dihydro-3H-naphtho[1,2-e][1,3]oxazin-3-ones via three-component reaction of arylaldehydes, urea, and β-naphthol are described. This method offers advantages such as easy work-up, low environmental impact, shortened reaction times, and high yields. The catalyst recovered was reused four times without significant loss of catalytic activity.

Keywords: Amberlite IRA-400 Cl resin, naphthoxazin-3-ones, solvent-free conditions, three-component reaction, green catalyst, therapeutic agents.

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